The Academy is officially represented on several national and international bodies. National bodies on which the Academy serves include the National Council for Tertiary Education, Ghana National Commission on UNESCO, the Medical and Dental Council, and the Council for Scientific and
Industrial Research (CSIR).

The Academy is also a member of international organizations such as the Third World Academy
of Sciences, the International Academic Union, African Academy of Sciences, Inter Academy Panel and International Council for Science (ICSU), etc.

Two fellows of the Academy, Professor Adzei Bekoe, and Professor D. A. Akyeampong have been President and Vice President respectively of ICSU. The Academy is also affiliated to the International Council for Philosophy and Humanistic Studies, CIPSH-UNESCO, the humanities equivalent of ICSU. A fellow of the Academy, Professor R. F. Amonoo was the Vice President and Honorary Treasurer of CIPSH for a number of years.

Until 1st January 2003, the Ghana Academy of Arts and Sciences also hosted the West African sub
regional office of the Committee on Science and Technology in Developing Countries (COSTED), which was formed in the seventies to advise the ICSU on science in developing countries.

The Academy has links with other international academies in Europe and USA. In April 2003, the Academy was invited by the US National Academies to be part of a capacity building workshop for African academies. Its Honorary Secretary, Professor Kwesi Yankah, represented the Academy.

The Academy played host in 2003 to a Fellow of the Royal Netherlands Academy, Professor Henk L.
Wesseling, a distinguished historian who gave public lectures and university seminars in Accra as well as the Universities of Ghana and Cape Coast. The Academy and the Royal Netherlands Embassy jointly sponsored Professor Wesseling's visit.In 2004 The The Ghana Academy of Arts and Sciences hosted a three-member delegation from the US National Academies. The purpose of the visit was to assess the eligibility of the Academy for sustained collaborative work and assistance on the interface between scientific research and national policy. This is in line with the Ghana academy of Arts and Sciences' objective of contributing actively to the development of Ghana and Africa generally, by examining and addressing critical issues of development.

Under a broad programme on African Science Development the US National Academies will assist
African Academies of Science to provide evidence-based advice that would inform government policy-making and public discourse, with a focus on improving human health. The ten-year initiative is supported by a grant from the Bill and Melinda Gates Foundation. The delegation to Ghana comprised the leader of the delegation, David Satcher, the 16 th Surgeon General of the United States of America. He is reputed to be the second in history to simultaneously hold the positions of Surgeon
General and Assistant Secretary for Health; Princeton Lyman, a former US Ambassador to Nigeria and to South Africa. He is currently Ralph Bunche Senior Fellow for Africa Policy Studies at the Council on Foreign Relations, and Clara Cohen, the Programme Officer at the International Affairs Office of the US National Academies.