Inaugural lectures, whether addressed to fellows or to the general public, have always focused on a contemporary issue of national or international significance. In 1995, when universities in Ghana were going through a major crisis, a fellow of the Academy gave an inaugural lecture on, 'Does Africa really Need her Universities?'. In 2003, there were two outstanding Inaugural Lectures: 'The Voyage from Birth to Death: Health Hazards for Ghanaians,' given by Professor J. O. M. Pobee and 'The Future of Cardio thoracic Surgery in Ghana' presented by Professor Kwabena Frimpong-Boateng. Both lectures focused on issues of health, life style, and resource development.

Two equally brilliant inaugural lectures were also given in 2004 by Dr. M.R. Appiah on the topic: "Impact of Cocoa Research on Poverty Alleviation in Ghana" and Prof. K Andam on the topic: "Bricks, Blocks and the Future Administrative Capital of Ghana". In 2005 the Academy held eight inaugural lectures in both the humanities and sciences comprising Prof. D.K. Agyeman on the topic 'The Ethnic Factor in National Development: Uses and Abuses'. Subsequently Prof. Aba Bentil Andam delivered her inaugural lecture on the topic 'Physics for Wealth Creation: The Ghanaian Experience'. Prof. Henrietta J.A.N. Mensa-Bonsu also gave her Inaugural lecture on the topic 'Ghana's Juvenile Justice System on Probation…Making Progress with Painful Steps and Slow'.
The first half of 2005 ended with the Inaugural lecture of Prof. V.P.Y. Gadzekpo, President, Central University College, Accra. His topic was 'Chemistry - The Neglected Element in the Industrialization Equation'. In November 2005 Prof. S.K.B. Asante followed with his Inaugural lecture on the topic 'Implementing the New Partnership for Africa's Development (NEPAD) Initiative: Challenges and the Path to Progress'.

Besides inaugural lectures, the Academy also has the annual lecture series, instituted in 1993, where Fellows take turns in addressing topical issues in the humanities and the sciences. In 2003 Dr. Leticia Obeng gave a lecture on 'Water: A Crisis in Development.' In 2004 Professor Kwesi Yankah addressed the topic: "Language, the Mass Media and Democracy in Ghana" in the Annual Humanities Lecture Series. His Lordship Chief Justice George Kingsley Acquah mounted the rostrum to give the Academy's 2005 Annual Lecture in the Humanities on the topic 'Parliamentary Vetting and Our Constitutional Democracy'. In October of 2005, Prof. J.C. Norman, FGA delivered the 2005 Annual Lecture in the Sciences on the topic 'The Landscape Industry in Sustainable Environmental Management'. On this occasion the Academy collaborated with the Ghana Institution of Horticulturists in holding this public event.